Latest Update of Hotfix /Service Pack

Hi,

we are using Microsoft SQL Server 2008 R2 (RTM) - 10.50.1600.1 (X64),in our data centre.

(Some of are in clustering & Mirroring & Log shipping ,Rest are  standalone installations )

which will the best sp or latest cumulative update package. 
? Can we go for -cumulative update package 13 (Build number: 10.50.4319.0) 
Which one we should go with . 

2008R2_SP2_MDS_CU13_2967540_10_50_4319_x64 
2008R2_SP2_SNAC_CU13_2967540_10_50_4319_x64 
SQLServer2008R2_SP2_CU13_2967540_10_50_4319_x64 
2008R2_SP2_RSShrPnt_CU13_2967540_10_50_4319_x64

Regards

Naveen

Regards Naveen MSSQL DBA